Methicillin—resistant staphylococcus aureus or MRSA
Andrew studied chemistry at the University of Oxford before he went on to apply these skills to investigate how life works at a molecular level. During his PhD at the University of Cambridge, he focused on how nature makes the antibiotics we use to treat antibiotic-resistant infections including MRSA. In 2009, he moved to the MRC Laboratory of Molecular Biology as a Career Development Fellow; here, investigated how the machinery within the cells interacts to undertake basic processes including the replication of DNA. In 2013, Andrew moved to the Cambridge Institute to focus on the molecular processes that drive breast cancer.
CRUK Cambridge Institute
Andrew is currently based at Cancer Research UK's Cambridge Institute where he leads a research team. His research programme brings together his experience of cutting edge mass spectrometry and DNA sequencing techniques to investigate the role of the oestrogen receptors (ER) in breast cancer. In 70% of all breast cancer cases, this receptor drives the growth and proliferation of the tumour, and is a key target for the drug Tamoxifen. He hopes to provide key insights into how the signalling within the cell dynamically regulates the ER. The output of his work will provide the potential to develop new therapies and the research technologies he has developed have already been applied by other research groups around the world.
Onstage at the Bloomsbury Theatre
Andrew has worked on many science outreach and public engagement projects including founding and organising Skeptics in the Pub in Cambridge, which holds monthly talks by various speakers with the aim of highlighting the application of critical thinking and scientific method. Notable speakers include popular non-fiction author Simon Singh, statistician David Spiegelhalter and historian Christopher Andrew.
His public engagement work has been supported by several organisation including the MRC; an hed was successful in his application for a Catalyst Award from UnLtd and the HEFCE for Social Entrepreneurship to help fund his work. His project received further funding from a Wellcome Trust People Award to produce a range of podcasts that support his events.
Andrew has been a guest on the The Naked Scientists Q&A radio show as Dr Andy, answering the public's questions on science. Futher to this, he produced and hosted this own radio show The Science of Fiction on CamFM on Sunday evenings that covered the science behind movies, books and TV shows. In 2014 it became a live show at the Cambridge Science Centre as part of the Festival of Ideas. He has also been involved in current news having been interviewed by BBC Radio 5 Live's 5 Live Drive and BBC Cambridgeshire on topical science stories.
He has worked with the BBC on several shows as part of a British Science Assocation Media Fellowship, including Horizon and The One Show and written for The Guardian's 'Comment is Free' section along with BlueSci magazine. In 2013 he presented his first show for the BBC World Service called ''What if ... we could all become Cyborgs'.
Cancer Research UK Cambridge Institute
University of Cambridge
Li Ka Shing Centre
Tel: +44 (0) 1223 769 500
E-mail: Andrew.Holding at cruk.cam.ac.uk